Take Lafayette/US Hwy. 90 exit (Exit 103) from I-10. Follow US Hwy. 90 through Lafayette toward New Iberia. At LA 14, exit and turn left. At LA 329 junction, turn right. Stay on LA 329 until you reach Avery Island.
Approximate drive time: 45 minutes–1 hour
Leave New Orleans on I-10 West. After passing the airport exit, get in the right lane and take the I-310 South exit marked Boutte.
Stay on I-310 South until you are forced to exit. Take the Hwy. 90 West exit (right lane, marked Houma). Stay on Hwy. 90 West all the way to New Iberia (four lanes the entire way). New Iberia is about 40 miles past Morgan City.
As you approach New Iberia, take the Avery Island (Hwy. 329) exit. At the stop sign at the end of the exit, take a left onto the Avery Island road (also called Hwy. 329), which will take you under the Hwy. 90 overpass.
Stay on Avery Island road for approximately 6 miles until it dead ends at the Avery Island tollgate.
Approximate drive time: 2–2 1/2 hours